Compound Monograph
Hyperoside
A flavonol glycoside (the galactoside of quercetin) found in hawthorn, St. John's Wort and many other plants.
Classification
Hyperoside is a flavonol glycoside, part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (9)
Hyperoside is a naturally occurring flavonol glycoside, found in Hawthorn, St. John's Wort and 7 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Hyperoside is a flavonol glycoside, specifically the 3-O-galactoside of quercetin, found widely in plants including hawthorn (where it is one of the characteristic flavonoids) and St. John’s Wort. It is studied as part of the flavonoid fraction of hawthorn, which is used traditionally to support cardiovascular function, and it shows antioxidant and anti-inflammatory activity in laboratory studies typical of quercetin-type flavonoids.
Toxicity & Safety
As a common dietary flavonoid glycoside, hyperoside is considered well tolerated. Dedicated high-dose human safety data for the isolated compound are limited.