Compound Monograph
1-Methylmalate
An organic-acid methyl ester isolated from camu-camu juice, reported hepatoprotective where plain malate was not.
Sources · 1
Where Does It Come From?
1-Methylmalate is a naturally occurring organic acid (malate methyl ester), found in Camu-camu. It is well tolerated orally (low toxicity).
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
1-Methylmalate is a methyl ester of malic acid isolated from camu-camu (Myrciaria dubia) juice. In rats it suppressed D-galactosamine-induced liver injury, lowering ALT and AST, while malate, citrate and tartrate tested alongside it did not (PMID 20208347). That selectivity is the reason the compound is singled out from the fruit’s wider organic-acid fraction; the finding is a single animal study and has no human counterpart.
Toxicity & Safety
No isolated-compound toxicity dataset exists. Exposure in food is as a minor juice acid, and the flag reflects that dietary context rather than a characterised safety profile.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
