Compound Monograph
Picolinic acid
A tryptophan-derived pyridine carboxylic acid and metal chelator; the ligand in zinc picolinate.
Sources · 1
Where Does It Come From?
Picolinic acid is a naturally occurring pyridine carboxylic acid, found in Endogenous. It is well tolerated orally (low toxicity).
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Picolinic acid is a pyridine-2-carboxylic acid formed endogenously along the kynurenine branch of tryptophan metabolism. It is a metal chelator, which is why it is used as a mineral-supplement ligand: zinc picolinate is elemental zinc bound to two molecules of picolinic acid. It also has a described role in immune signalling.
Toxicity & Safety
Picolinic acid is produced endogenously and consumed in chelated mineral supplements with a long use record. No isolated-compound toxicity dataset at supplemental doses was located.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
