Compound Monograph
Cananodine
A guaipyridine sesquiterpene alkaloid from ylang-ylang fruit, cytotoxic to hepatocarcinoma cell lines in vitro.
Sources · 1
Where Does It Come From?
Cananodine is a naturally occurring guaipyridine sesquiterpene alkaloid, found in Ylang-ylang. It is flagged as moderately toxic.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Cananodine is a guaipyridine-type sesquiterpene alkaloid isolated from the fruit of Cananga odorata — notably from the fruit rather than the essential oil that ylang-ylang is otherwise known for. It showed cytotoxicity against the human hepatocarcinoma lines Hep-G2 and Hep-3B (PMID 11374955). The activity is in vitro only and has not advanced to animal or clinical testing.
Toxicity & Safety
The only reported activity is cell-line cytotoxicity, and no isolated-compound safety dataset exists. It is not a constituent of the distilled flower oil, so ordinary aromatic use of ylang-ylang does not involve exposure to it.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
