Compound Monograph
Crataemine
A quinolone alkaloid first described from Crataeva nurvala stem bark, cytotoxic to several tumour cell lines.
Sources · 1
Where Does It Come From?
Crataemine is a naturally occurring quinolone alkaloid, found in Varuna. It is flagged as moderately toxic.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Crataemine (5,7-dimethoxy-3-phenyl-1-ethyl-1,4-dihydro-4-quinolone) is one of two novel compounds reported from Crataeva nurvala stem bark, alongside the steroidal glycoside crataenoside. Both were cytotoxic to HeLa, PC-3 and MCF-7 cells and blocked migration and colony formation in the more aggressive lines (PMID 23354071). This is a single isolation-and-screening paper; nothing further has been published on the compound.
Toxicity & Safety
The reported activity is cell-line cytotoxicity and no isolated-compound safety dataset exists. The flag is conservative and reflects that cytotoxic screening profile rather than a characterised toxicology.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
