Compound Monograph
N-Isobutyldodeca-2E,4E,8Z,10E/Z-tetraenamide
The major alkylamide of Echinacea root and its usual quality-control marker — one of the compounds behind the tingling sensation, and cannabinoid-receptor active in the laboratory.
Sources · 1
Where Does It Come From?
N-Isobutyldodeca-2E,4E,8Z,10E/Z-tetraenamide is a naturally occurring fatty acid amide (n-alkylamide), found in Echinacea. It is well tolerated orally (low toxicity).
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
This dodeca-2E,4E,8Z,10E/Z-tetraenamide is one of the major and most studied alkylamides of Echinacea root, usually present as a mixture of the 10E and 10Z isomers. It is among the constituents responsible for the characteristic tingling sensation of Echinacea preparations and is frequently used as a marker compound in quality control. Like other Echinacea alkylamides it has shown cannabinoid-receptor binding and immune-modulating activity in laboratory studies, though human clinical data remain limited.
