Compound Monograph
Neurokinin B
Neurokinin B is a mammalian signaling peptide of the tachykinin family that acts mainly at the NK3 receptor.
Sources
Where Does It Come From?
Neurokinin B is a naturally occurring (and made in the body) tachykinin (neuropeptide). It is well tolerated orally (low toxicity).
Research & Evidence
Neurokinin B is a decapeptide belonging to the tachykinin family of neuropeptides, which also includes substance P and neurokinin A. It is produced in the body and brain, where it preferentially activates the NK3 (tachykinin) receptor. It is best known for its role in reproductive neuroendocrine signaling, including the regulation of gonadotropin-releasing hormone, and is also studied in the context of hot flushes and other physiological processes. Despite appearing here alongside amphibian “Kambo” peptides, neurokinin B is an endogenous mammalian peptide rather than a plant or frog skin product.
Toxicity & Safety
As a naturally occurring signaling peptide, neurokinin B is not a dietary or recreational substance and has no established toxicity profile in that sense. Its actions are studied mainly through pharmacology and receptor research rather than ingestion.
