Compound Monograph
Proamanullin
Proamanullin is a minor cyclic peptide of the amatoxin family found in deadly Amanita mushrooms.
Sources · 1
Where Does It Come From?
Proamanullin is a naturally occurring cyclic peptide (amatoxin), found in Death cap and related Amanita mushrooms. It is flagged as toxic.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Proamanullin is a bicyclic octapeptide belonging to the amatoxin group produced by certain deadly Amanita mushrooms. It is structurally related to the well-known toxin alpha-amanitin. Despite a source tag suggesting otherwise, it is not a tryptamine or a psychedelic; the amatoxins are inhibitors of RNA polymerase II, the same mechanism that makes this mushroom family lethal. Proamanullin is a comparatively minor congener and is not well characterized on its own.
Toxicity & Safety
As a member of the amatoxin family, proamanullin should be regarded as part of a class of compounds responsible for fatal mushroom poisonings; amatoxins cause severe liver and kidney damage. These mushrooms have no safe use, and any suspected ingestion is a medical emergency.
