Compound Monograph
Spilanthol
Spilanthol is the pungent alkylamide responsible for the tingling, numbing sensation of electric daisy (Acmella oleracea).
Sources · 2
Where Does It Come From?
Spilanthol is a naturally occurring alkylamide (n-isobutylamide), found in Electric daisy and 1 other source. It is well tolerated orally (low toxicity).
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Spilanthol is an unsaturated isobutylamide and the main pungent principle of electric daisy (toothache plant), producing the characteristic tingling, salivating and locally numbing sensation when the flower heads are chewed. This is the basis of the plant’s traditional use for toothache and oral discomfort. It has also been examined for local anesthetic, anti-inflammatory and insecticidal properties, mostly in laboratory studies.
Toxicity & Safety
At the levels encountered in the plant and in oral-care products, spilanthol is generally well tolerated, its most obvious effect being the transient tingling and numbness. Its safety in concentrated form has not been formally characterized.
