Compound Monograph
4-O-Methylhonokiol
A methylated honokiol derivative from magnolia bark, studied alongside honokiol and magnolol in preclinical Alzheimer's models.
Sources · 1
Where Does It Come From?
4-O-Methylhonokiol is a naturally occurring neolignan, found in Magnolia. Its toxicity is not yet characterized.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
4-O-Methylhonokiol is a neolignan of Magnolia bark and a methyl ether of honokiol. Systematic reviews of preclinical anti-Alzheimer’s work report it, honokiol and magnolol improving learning and memory in animal models by inhibiting amyloid-β generation and aggregation, curbing neuroinflammation, inhibiting acetylcholinesterase and reducing oxidative stress. All of this is animal and cell work; no human trial of the isolate exists.
Toxicity & Safety
No isolated-compound toxicity dataset was located. The magnolia neolignans as a group are reasonably well tolerated in animal work, but that does not characterise this derivative specifically.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
