Compound Class

Phenolics

Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.

661 Constituents17 Subclasses211 Source herbs

Overview

What Are Phenolics?

Phenolics are organic compounds built around at least one phenol unit — an aromatic ring carrying one or more hydroxyl groups. Where a molecule strings several such rings together it is termed a polyphenol.

Those reactive hydroxyl groups readily donate hydrogen and neutralize free radicals, which is the structural root of the group's reputation as antioxidants. Phenolics form the largest single group of plant-derived antioxidants and are among the most abundant compounds in both the herbal materia medica and the ordinary diet.

01

Where Phenolics Occur

Almost every plant tissue examined carries phenolics in some quantity. They color flowers and fruit, screen leaves against ultraviolet light, deter grazing insects and defend against microbial attack. Particularly rich sources include:

Berries and other deeply colored fruits

Tea, cocoa and coffee

Barks, leaves and unripe fruit (tannins)

Culinary and aromatic herbs

Legumes, especially soya and red clover (isoflavones)

Because they are so widespread, phenolics account for a large share of everyday dietary antioxidant intake, not just medicinal use.

02

Defining the Class

A compound qualifies as a phenolic when it bears a hydroxyl group bonded directly to an aromatic ring. Classification rests on that shared structural signature rather than on any single biological effect.

From that common motif the subgroups diverge widely in size and behavior, from a simple phenolic acid of a few atoms to a condensed tannin large enough to bind and precipitate proteins.

03

Pharmacological Importance

Phenolics are the antioxidant and anti-inflammatory workhorses of plant medicine. The flavonoids are valued for vaso-protective and capillary-strengthening activity, the tannins for astringent tissue-toning, and the phenolic acids for gentle dietary-level antioxidant effects.

Several subgroups carry more specific pharmacology: the isoflavones act as phytoestrogens, the anthraquinones are the stimulant laxative principle of senna and cascara, and the curcuminoids of turmeric are among the most studied anti-inflammatories in the plant kingdom.

04

Toxicity & Safety

As a class the pattern is reassuring. Most phenolics are consumed daily without incident and are very well tolerated.

The exceptions are worth naming honestly: coumarin carries modest concerns at concentrated intake, hydroquinone and its glycoside arbutin attract caution, tannins in quantity are strongly astringent and can hinder mineral absorption, and the anthraquinones are purgative with habitual use. These are footnotes to a broadly gentle group rather than the rule.

Constituents

All Phenolics

661 total

#

1,5-di-O-caffeoylquinic acid 1 herb 10-Gingerol 1 herb 2-Hydroxy-3-methyl-quinone 1 herb 2-Hydroxymethyl-anthraquinone 1 herb 2-Phenylethanol 1 herb 3,5-Dicaffeoylquinic Acid 5 herbs 4-Hydroxybenzoic acid 1 herb 4-Hydroxybenzyl Alcohol 1 herb 4-Hydroxycinnamic acid 1 herb 4-Hydroxycinnamoyl-quinic acid 1 herb 4-Methoxyphenol 1 herb 4-O-Methylhonokiol 1 herb 4,5-Dicaffeoylquinic Acid 3 herbs 5-O-caffeoylquinic acid 1 herb 5-O-Caffeoylshikimic acid 1 herb 6-Demethoxycapillarisin 1 herb 6-Gingerol 1 herb 6-Hydroxy-7-methoxycoumarin 1 herb 6-Hydroxy-mellein 1 herb 6-Hydroxykaempferol 3,6-dimethyl ether 1 herb 6-Methoxyhesperetin 1 herb 6-Methoxynaringenin 1 herb 6-Paradol 1 herb 6-Prenylnaringenin 1 herb
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Source Plants

Herbs Containing Phenolics

211 herbs

Plants in the materia medica documented to carry phenolics, with the compounds each one is listed for. The bar counts how many DISTINCT phenolics are on record for a plant, relative to the best-documented — it measures breadth of record, not potency, so a plant with one well-studied compound can outrank a richer source that has simply been analysed less. Where a measured concentration is on record it is quoted inline; most entries have none yet.

Pau D'Arco Tabebuia impetiginosa Documented for 2-hydroxy-3-methyl-quinone, 2-hydroxymethyl-anthraquinone, 4-methoxyphenol and 36 more phenolics. 39 Phenolics Licorice Glycyrrhiza glabra Documented for glabridin (0.08–0.35 % dry wt), glycyrrhisoflavone (0.02–0.09 % dry wt), chalcones and 22 more phenolics. 25 Phenolics Bearberry Arctostaphylos uva-ursi Documented for pentagalloylglucose (6.6–12.9 mg/g dry wt), arbutin, corilagin and 18 more phenolics. 21 Phenolics Hops Humulus lupulus Documented for 6-prenylnaringenin (0 % dry wt), 8-prenylnaringenin, astragalin and 18 more phenolics. 21 Phenolics Sarsaparilla Smilax spp. Documented for 5-O-caffeoylshikimic acid, astilbin, caffeic acid and 18 more phenolics. 21 Phenolics Meadowsweet Filipendula ulmaria Documented for tellimagrandin II (2.02 mg/100 mL), hyperoside, kaempferol and 17 more phenolics. 20 Phenolics Cramp Bark Viburnum opulus Documented for arbutin, caffeic acid, catechin and 16 more phenolics. 19 Phenolics Passionflower Passiflora incarnata Documented for apigenin, chrysin, coumarin and 16 more phenolics. 19 Phenolics Feverfew Tanacetum parthenium Documented for 6-hydroxykaempferol 3,6-dimethyl ether, apigenin, carvacrol and 15 more phenolics. 18 Phenolics Globe Artichoke Cynara scolymus Documented for caffeic acid, caffeoylquinic acids, chlorogenic acid and 15 more phenolics. 18 Phenolics Stinging Nettle Urtica dioica Documented for astragalin, caffeic acid, chlorogenic acid and 15 more phenolics. 18 Phenolics Black Walnut Juglans nigra Documented for carvacrol, ellagic acid, ellagitannins and 14 more phenolics. 17 Phenolics

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