Compound Monograph
Bufotenidine
Bufotenidine is a quaternary tryptamine derivative found in toad venom and some plants.
Sources · 1
Where Does It Come From?
Bufotenidine is a naturally occurring tryptamine alkaloid (quaternary ammonium), found in Toad venom. It is flagged as toxic.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Bufotenidine is a quaternary trimethylated tryptamine derivative related to serotonin and bufotenin, reported from toad venoms and some plant sources. Because it carries a permanent positive charge, it does not readily cross the blood-brain barrier, and it is generally regarded as acting peripherally rather than as a centrally active psychedelic. It has been noted to have effects on smooth muscle and the cardiovascular system in laboratory studies.
Toxicity & Safety
As a constituent of toad venom, bufotenidine is associated with peripheral, primarily cardiovascular and smooth-muscle activity rather than psychedelic effects, and venom-derived tryptamine derivatives of this kind can be toxic. Isolated human safety data are limited.
