Compound Monograph

Codeine-N-oxide

Alkaloids Isoquinoline Alkaloids Natural (plant-derived)

Codeine-N-oxide is an N-oxide derivative of the opium alkaloid codeine.

Sources · 1

Where Does It Come From?

Codeine-N-oxide is a naturally occurring opium (morphinan) alkaloid, found in Opium poppy. It is flagged as toxic.

Also found in
Opium poppy Monograph coming soon

Concentration

Content by Source

Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.

Research & Evidence

Codeine-N-oxide is an N-oxide derivative of codeine, the well-known opium alkaloid from the poppy. It is a minor compound related to the morphinan group of opiates and has been little studied in its own right. In the United States it is listed as a Schedule I controlled substance.

Toxicity & Safety

As an opiate-related compound it should be regarded as potentially hazardous, with the dangers common to opioids, and it is a Schedule I controlled substance in the United States. Its isolated pharmacology and safety profile are not well characterized.