Compound Monograph
Dihydroergotoxine
Dihydroergotoxine is a mixture of hydrogenated ergot alkaloid mesylates historically used to treat age-related cognitive decline.
Sources · 1
Where Does It Come From?
Dihydroergotoxine is a semi-synthetic ergot alkaloid (hydrogenated mixture), found in Ergot fungus , as semi-synthetic derivatives. It is flagged as moderately toxic.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Dihydroergotoxine, also known as ergoloid mesylates or co-dergocrine, is a standardized mixture of dihydrogenated ergot alkaloids derived from compounds produced by the ergot fungus Claviceps purpurea. It acts on adrenergic, dopaminergic and serotonergic receptors and was marketed for many years as a treatment for symptoms of age-related cognitive decline and cerebrovascular insufficiency, though its clinical benefit has been regarded as modest and uncertain.
Toxicity & Safety
As an ergot derivative it can cause gastrointestinal upset, nasal congestion and, rarely, vasoconstrictive effects. It is generally contraindicated in people with significant hypotension or acute or chronic psychosis.
