Compound Monograph
Entagenic acid
The oleanane sapogenin of Entada saponins, reported to suppress nitric oxide and inflammatory cytokines in macrophages.
Sources · 1
Where Does It Come From?
Entagenic acid is a naturally occurring oleanane triterpene sapogenin, found in Entada phaseoloides. Its toxicity is not yet characterized.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Entagenic acid is the oleanane-type aglycone of the Entada stem saponins. It and its glycosides suppressed nitric-oxide production and TNF-α, IL-1β, IL-6 and IL-8 release in LPS-stimulated macrophages at roughly 20–25 µM (PMID 25759122). Note the species: this work is on Entada phaseoloides, not the E. rheedii of African dream herb — the read-across between the two species has not been confirmed.
Toxicity & Safety
No isolated-compound toxicity data were located, and the cross-species attribution above is itself unresolved. Triterpene sapogenins are locally irritant as a class.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
