Compound Monograph
Formononetin
Formononetin is an isoflavone phytoestrogen found in red clover and other legumes.
Sources · 5
Where Does It Come From?
Formononetin is a naturally occurring flavonoid (isoflavone), found in Red clover, Other legumes and 3 other sources. It is well tolerated orally (low toxicity).
Source Astragalus Astragalus mongholicus Herb monograph → 
Source Black Cohosh Cimicifuga racemosa Herb monograph → 
Source Licorice Glycyrrhiza glabra Herb monograph → Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Formononetin is an isoflavone found in red clover and various legumes. It is a phytoestrogen, meaning it can interact weakly with estrogen receptors, and in the body it can be converted to the related isoflavone daidzein. It is one of the constituents studied in connection with red clover preparations used for menopausal and other indications, though clinical evidence for the isolated compound is limited.
Toxicity & Safety
As a dietary isoflavone, formononetin is generally regarded as low risk at the levels obtained from foods and herbal preparations. Because of its phytoestrogenic activity, people with hormone-sensitive conditions may wish to be cautious with concentrated isoflavone supplements and seek individual advice.
