Compound Monograph
Hydrangeic acid
A stilbene of Asian hydrangea leaf with a PPARγ-agonist-like antidiabetic profile in preclinical work.
Sources · 1
Where Does It Come From?
Hydrangeic acid is a naturally occurring stilbene, found in Hydrangea — Asian leaf. Its toxicity is not yet characterized.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Hydrangeic acid is a stilbene of the Asian sweet-tea hydrangea leaf (Hydrangeae Dulcis Folium). With hydrangenol and phyllodulcin it promotes adipocyte differentiation and adiponectin release with a profile like a PPARγ agonist — but without directly binding the receptor, unlike the thiazolidinediones (PMIDs in the hydrangea monograph). It is reported from the Asian species, not from the American H. arborescens that the hydrangea monograph here otherwise covers.
Toxicity & Safety
No isolated-compound toxicity dataset exists. The species caveat above matters for any safety read-across.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
