Compound Monograph
Otobaphenol
A neolignan of Virola resin reported to block iron/ascorbate-driven mitochondrial lipid peroxidation.
Sources · 1
Where Does It Come From?
Otobaphenol is a naturally occurring neolignan, found in Epena. Its toxicity is not yet characterized.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Otobaphenol is a neolignan of Virola species. It blocked iron/ascorbate-driven mitochondrial lipoperoxidation and delayed the mitochondrial permeability transition, part of a broad and well-replicated antioxidant theme across the genus’s lignans — aryltetralone lignans from Virola sebifera inhibited lipid peroxidation more effectively than α-tocopherol in vitro. All of it is in-vitro work.
Toxicity & Safety
No isolated-compound toxicity dataset exists. Note that Virola resin is the source of a psychoactive snuff; the lignan fraction discussed here is not the psychoactive part, which is the tryptamines.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
