Compound Monograph
Ginkgolides
Distinctive terpene trilactones unique to Ginkgo biloba and known as antagonists of platelet-activating factor.
Sources · 1
Where Does It Come From?
Ginkgolides are naturally occurring terpene trilactone (diterpenoid), found in Ginkgo. They are well tolerated orally (low toxicity).
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Ginkgolides are a group of complex terpene trilactones (ginkgolides A, B, C and others) found uniquely in Ginkgo biloba, where together with the bilobalide they make up the terpene fraction of standardized leaf extracts. Their best-characterized pharmacological property is antagonism of platelet-activating factor (PAF), a mediator involved in inflammation, blood-vessel tone and platelet aggregation. Ginkgolide B in particular has been studied for this activity, and the terpene trilactones are part of why ginkgo extract is investigated for circulatory and cognitive applications.
Toxicity & Safety
At the levels present in standardized ginkgo extracts the ginkgolides are generally well tolerated. Because of their effects on PAF and platelet function, ginkgo extract may add to the effect of antiplatelet or anticoagulant medication, which is the main practical caution.
