Compound Monograph
Icaritin
A prenylflavonoid best known from Epimedium, also reported in shepherd's purse, studied for PCSK9-mediated cholesterol lowering.
Sources · 2
Where Does It Come From?
Icaritin is a naturally occurring prenylflavonoid, found in Shepherd's purse and Horny goat weed. Its toxicity is not yet characterized.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Icaritin is a prenylated flavonoid, best known as an Epimedium aglycone but also reported at around 17.5 mg/kg of a Capsella bursa-pastoris ethanol extract. That extract lowered serum total and LDL cholesterol in obese mice and in HepG2 cells by suppressing PCSK9 through the SREBP2 and HNF-1α transcription factors, additively with a statin — an effect attributed to its icaritin content (PMID 33673187).
Toxicity & Safety
No isolated-compound safety dataset is cited here. Prenylflavonoids of this family have reported oestrogenic activity, which is worth resolving before any use claim is made.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
