Compound Monograph
Safrole
Safrole is a naturally occurring phenylpropanoid and the characteristic aroma compound of sassafras, classed as a carcinogen.
Sources · 4
Where Does It Come From?
Safrole is a naturally occurring phenylpropanoid (methylenedioxy-substituted), found in Nutmeg, Sassafras, Star anise and 1 other source. It is flagged as toxic and a known carcinogen.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Safrole is a naturally occurring oil found in sassafras and, in smaller amounts, in nutmeg, star anise and other spices. It is the main constituent of sassafras oil and was historically used as a flavoring and fragrance. It is also the principal precursor used in the illicit synthesis of MDMA, which is the main reason it is regulated.
Toxicity & Safety
Safrole is a recognized hepatocarcinogen in animal studies and is banned as a food additive in many countries, including the United States. Its use as a flavoring agent has been prohibited on that basis, and exposure is best avoided.
