Compound Monograph
Tussilagonone
A coltsfoot sesquiterpenoid and structural analogue of tussilagone — Nrf2-active and cytoprotective in cell studies, and anti-inflammatory in a mouse model of psoriasis.
Sources · 1
Where Does It Come From?
Tussilagonone is a naturally occurring sesquiterpenoid, found in Coltsfoot. Its toxicity is not yet characterized.
Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Tussilagonone is a sesquiterpenoid of Tussilago farfara and a structural analogue of tussilagone. It induces NQO1 and HO-1 via Nrf2 and is cytoprotective in HepG2 cells, and it attenuated psoriasis-like skin inflammation in an imiquimod mouse model — one strand of a broader convergence in which multiple isolated coltsfoot sesquiterpenoids independently inhibit LPS-induced nitric oxide and cytokine release in microglia and macrophages.
Toxicity & Safety
No isolated-compound toxicity dataset exists. The safety issue with coltsfoot is not its sesquiterpenoids but its hepatotoxic pyrrolizidine alkaloids, which are a whole-herb concern and are covered on the coltsfoot monograph and the PA pages.
Placeholder entry — a full monograph is pending via the compound-expansion worklist.
