The cause of interstitial cystitis is unknown, but it has a strong prevalence in middle aged caucasian women, and those suffering from IBS. This has led to some calling the condition “IBS of the bladder”.

Factors That May be Involved in The Development Of Interstitial Cystitis:

• History of infection
• Leaky urothelium
• Autoimmune conditions
• Irritating hemicals in the urine
• Reduced nitric oxide synthase activity
• Neurogenic inflammation involving the mast cells
• Stress
• Chronic inflammation
• Lowered bladder mucosa integrity
• Mast cell degranulation

Interstitial cystitis presents with chronic pelvic or bladder pain and pressure that often eases after urination, along with urinary frequency, urgency, and night-time urination. Symptoms may fluctuate and can be aggravated by certain foods, stress, or, in women, the menstrual cycle.

The average time from the onset of symptoms to diagnosis of interstitial cystitis is 5 years. ^{1Reference 1Murray et al. · 1998Encyclopedia of natural medicine}.

• microbiology of urine
  • E. coli
• High WBC in urine

• vaccinum macrocarpon
• gotu kola
• aloe vera