Compound Monograph
Humulene
A sesquiterpene that contributes to the aroma of hops and is found in many plant essential oils.
Sources · 6
Where Does It Come From?
Humulene is a naturally occurring sesquiterpene, found in Hops, Cannabis, Various aromatic plants and spices and 3 other sources. It is well tolerated orally (low toxicity).
Principal source Hops Humulus lupulus Herb monograph → 
Source Cannabis Cannabis sativa Herb monograph → 
Source Chir Pine Pinus roxburghii Herb monograph → 
Source Muira Puama Ptychopetalum olacoides Herb monograph → 
Source Sage Salvia officinalis Herb monograph → Concentration
Content by Source
Concentrations not reported. No percent-dry-weight or mg/g figures have been published for this compound in its source plants.
Research & Evidence
Humulene (alpha-humulene) is a sesquiterpene named after hops (Humulus lupulus), to whose aroma it contributes, and it is also widespread in other aromatic plants including cannabis, sage and ginger. It is structurally related to beta-caryophyllene, with which it often co-occurs. In laboratory studies it shows anti-inflammatory and antimicrobial activity typical of many sesquiterpenes, and it is of interest as an aroma component.
Toxicity & Safety
Humulene occurs naturally in hops, spices and other foods and is regarded as well tolerated at those levels. As with other concentrated essential-oil terpenes, undiluted material may irritate skin in sensitive individuals.
