Compounds & Supplements
Supplements Database
Nootropics, vitamins, minerals, amino acids, peptides and other isolated compounds — with mechanisms, dosage, and the evidence behind them. Filter by function (what you'd take it for), then narrow by class and action. For the deeper chemistry of any class, follow it through to the constituent browser.
Every published supplement, listed alphabetically. Pick a function above to read what it's for and the kinds of compounds used — then narrow by class and action in the sidebar.
5-HTP
Amino acid (serotonergic)
The direct precursor to serotonin — a serotonergic amino acid supplement used for mood, appetite and sleep, usually extracted from Griffonia simplicifolia seeds.
Alpha-GPC
Cholinergic
A choline-dense phospholipid used to raise acetylcholine — the best evidence is in dementia and stroke recovery, and it is much thinner for healthy-brain enhancement.
Aniracetam
Racetam
A fat-soluble racetam — a more potent relative of piracetam used for memory, focus and mood, with mild anxiolytic effects.
Bio PQQ
Quinone cofactor
Pyrroloquinoline quinone — a redox cofactor studied for mitochondrial support, antioxidant activity and nerve growth factor.
Caffeine
Methylxanthine alkaloid
Caffeine is perhaps the most popular stimulant in the world. It's contained within 3 of the most popular beverages the world has ever seen; coffee, tea, and yerba maté.
Choline Alfoscerate
Cholinergic
Choline alfoscerate (Alpha-GPC) — a highly bioavailable choline donor and acetylcholine precursor.
Creatine
Amino acid derivative
The most-researched sports supplement — a phosphocreatine energy buffer for muscle and, increasingly, the brain.
Huperzine-A
Alkaloid (acetylcholinesterase inhibitor)
Huperzine-A is an alkaloid extracted from various species of [Chinese club moss (Huperzia serrata)](/clubmoss). Its nootropic action comes from its ability to inhibit acetylcholinesterase, which is the enzyme that deaminates (breaks down) the neurotransmitter acetylcholine.
Inositol
Sugar alcohol (pseudovitamin)
A sugar-alcohol "pseudovitamin" and cellular second-messenger precursor used for mood, anxiety, PCOS and insulin sensitivity.
L-Carnitine
Amino acid derivative
An amino-acid derivative that ferries fatty acids into mitochondria to be burned for energy.
L-Theanine
Amino acid
A calming amino acid from tea that takes the edge off caffeine without sedation.
L-Tyrosine
Amino acid
Amino-acid precursor to dopamine and noradrenaline; buffers cognition under acute stress, cold and sleep loss.
Magnesium Citrate
Mineral
A well-absorbed, widely used magnesium salt — a solid all-purpose choice that doubles as a gentle laxative at higher doses.
Magnesium Glycinate
Mineral
Magnesium chelated to the amino acid glycine — the gentlest, best-tolerated form, favoured for calm, sleep and sensitive stomachs.
Magnesium L-Threonate
Mineral
A magnesium form marketed for cognition and "brain magnesium" — mechanistically interesting, but with limited and largely industry-funded human evidence.
Modafinil
Eugeroic (wakefulness-promoting agent)
A prescription wakefulness-promoting agent (eugeroic) for narcolepsy and shift-work sleep disorder, used off-label for focus.
NMN (Nicotinamide mononucleotide)
NAD+ precursor (nucleotide)
NMN is a nucleotide precursor to NAD+, taken to raise NAD+ levels and studied for longevity, metabolism, and physical performance in early human trials.
Noopept
Peptide nootropic
Noopept is a synthetic nootropic substance with effects very similar to piracetam.
Phosphatidylcholine
Phospholipid
The major membrane phospholipid and a dietary source of choline for acetylcholine, membranes, and methyl metabolism.
Phosphatidylserine
Phospholipid
A phospholipid building block of neuronal cell membranes — supplemented to support memory, focus and the stress response, especially with age. The pivotal older data used bovine-cortex PS; the modern soy/sunflower product has weaker evidence.
Piracetam
Racetam
The original nootropic (1964) and prototype racetam — mild memory and cognitive support with a very high safety margin.
Pramiracetam
Racetam
A fat-soluble, high-potency racetam that strongly enhances high-affinity choline uptake.
Pterostilbene
Stilbenoid polyphenol
A methylated, more-bioavailable cousin of resveratrol — a stilbenoid polyphenol from blueberries studied as an antioxidant.
Taurine
Amino acid (conditionally essential)
Taurine is a conditionally essential amino acid studied for cardiovascular support, exercise performance, and metabolic health.
Uridine Monophosphate
Nucleotide
A nucleotide that supports synaptic membrane synthesis and works with choline donors for cognition.
Vinpocetine
Alkaloid derivative (vasodilator)
Vinpocetine is one of the first nootropic substances to hit the mainstream public. The chemical is a derivative of a naturally occurring compound known as vincamine extracted from the periwinkle plant.
Vitamin B12
Vitamin
Cobalamin — the cobalt-containing B vitamin needed for red-blood-cell formation, DNA synthesis and the upkeep of the nervous system; found almost only in animal foods.
Vitamin B6
Vitamin
Pyridoxine — a water-soluble B vitamin whose active PLP form is a cofactor for amino-acid metabolism and the synthesis of serotonin, dopamine and GABA.
Vitamin B9
Vitamin
Folate — the water-soluble B vitamin behind DNA synthesis and cell division, essential before and during early pregnancy to prevent neural-tube defects.
Vitamin D3 (Cholecalciferol)
Vitamin (fat-soluble) / secosteroid
Vitamin D3 (cholecalciferol) is a fat-soluble secosteroid vitamin, made in skin from sunlight, essential for calcium absorption and bone health.
Zinc
Mineral
An essential trace mineral and cofactor for hundreds of enzymes — central to immunity, wound healing, growth and male hormone regulation.
No supplements match these filters.