Rosmarinic Acid

Rosmarinic Acid at a Glance

Rosmarinic acid is the signature polyphenol of the mint family — a caffeic-acid ester so characteristic of Lamiaceae that it serves as a chemotaxonomic marker for the family, present in rosemary, lemon balm, perilla, sage and spearmint.

Its human evidence is genuine and unusually varied — cognition and attention, allergic rhinitis, anxiety and sleep — but it comes almost entirely from standardised herb extracts rather than the purified compound: perilla for allergy, spearmint for cognition, lemon balm for mood.

That makes it a molecule whose clinical record is real but attached to specific preparations, which is worth carrying into any claim made for the isolate.

What It's Used For

Rosmarinic acid is the signature polyphenol of the mint family — the compound that gives rosemary, lemon balm, perilla, sage, oregano and spearmint much of their antioxidant and anti-inflammatory character, and a reliable chemotaxonomic marker of the Lamiaceae (and Boraginaceae). It has a genuine and unusually human evidence base for a plant phenolic: real randomized trials in seasonal allergy, attention and memory, anxiety and knee osteoarthritis. But there is one caveat that governs the entire page, and it is not a minor one: essentially none of that evidence used isolated rosmarinic acid. Every positive trial used a standardized herb extract — perilla, spearmint or lemon balm — in which rosmarinic acid is the marker and a plausible active within a polyphenol mixture ^{1,2Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →}.

On top of that, rosmarinic acid is poorly absorbed and heavily metabolized to smaller phenolics (caffeic, ferulic acids) ^{11Reference 11Baba S et al. · 2005Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humansView study →}.

So the honest reading is: promising herbal evidence, credited to a marker molecule, not proof of the isolate.

The evidence is extract evidence, not isolate evidence.No verified human RCT tested purified rosmarinic acid — all used perilla, spearmint or lemon balm standardized to it ^{1,2Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →}.

Seasonal allergy — the cleanest signal:a rosmarinic-acid-enriched perilla extract reduced allergic rhinoconjunctivitis symptoms and nasal inflammatory cells ^{1Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →}.

Attention & working memory:a high-rosmarinic-acid spearmint extract (Neumentix, ~130 mg/day) improved working memory and sustained attention in RCTs — though industry-sponsored ^{2,3Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →Reference 3Falcone PH et al. · 2019RCTThe attention-enhancing effects of spearmint extract supplementation in healthy men and women — a randomized, double-blind, placebo-controlled, parallel trialView study →}.

Anxiety, mood & sleep:lemon balm extracts reduce anxiety and depressive symptoms in a meta-analysis of small trials ^{8Reference 8Ghazizadeh J et al. · 2021Meta-analysisThe effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials — a systematic review and meta-analysisView study →}.

Knee osteoarthritis:high-rosmarinic-acid spearmint tea lowered WOMAC pain vs ordinary spearmint tea ^{5Reference 5Connelly AE et al. · 2014High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptomsView study →}.

Poorly bioavailable:oral rosmarinic acid is largely converted to caffeic/ferulic acids and conjugates before it reaches the circulation ^{11Reference 11Baba S et al. · 2005Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humansView study →}.

Evidence by IndicationStrength of support · Beta

Support is an experimental score I’m building — a composite weighted by study type (human > animal > in vitro > review) and study volume, tempered for isolate-vs-source match and bioavailability. It’s a beta: a fast way to rank strength of evidence at a glance, not a validated metric. Every score here is capped because the trials used standardized extracts, not isolated rosmarinic acid (the “Rests on” column names the vehicle). Each application links to its write-up.

The most-replicated modern signal, all from one branded extract. A high-rosmarinic-acid spearmint extract (Kemin “Neumentix”, standardized to ≥14.5% rosmarinic acid, ~900 mg/day ≈ 130 mg RA) improved quality of working memory (+15%) and spatial working-memory accuracy in older adults with age-associated memory impairment ^{2Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →}, improved sustained attention (~11%) in healthy active adults ^{3Reference 3Falcone PH et al. · 2019RCTThe attention-enhancing effects of spearmint extract supplementation in healthy men and women — a randomized, double-blind, placebo-controlled, parallel trialView study →}, and improved reactive agility and post-exertion executive function in further trials ^{4Reference 4Falcone PH et al. · 2018RCTEfficacy of a nootropic spearmint extract on reactive agility — a randomized, double-blind, placebo-controlled, parallel trialView study →}.

Lemon balm extracts add a modest cognitive signal — slowing neuropsychiatric decline in mild Alzheimer’s/MCI ^{9Reference 9Noguchi-Shinohara M et al. · 2020Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progressionView study →} and improving cognition in older adults without dementia ^{10Reference 10Noguchi-Shinohara M et al. · 2023RCTEffects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia — a randomized controlled trialView study →}.

Gap: these are extract trials (a polyphenol mixture, RA the marker), the flagship cognition work is industry-sponsored (Kemin), and effect sizes are modest — none isolates rosmarinic acid’s own contribution ^{2,3Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →Reference 3Falcone PH et al. · 2019RCTThe attention-enhancing effects of spearmint extract supplementation in healthy men and women — a randomized, double-blind, placebo-controlled, parallel trialView study →}.

Mechanisms

Target / pathway	Effect	Relevant to	Evidence
NF-κB / TNF-α, IL-1β, IL-6, COX-2 suppression	anti-inflammatory	allergyOA	review of preclinical ^{15Reference 15Luo C et al. · 2020ReviewA review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseasesView study →}
Mast-cell / eosinophil & neutrophil inhibition	anti-allergic	allergic rhinitis	human (extract) + preclinical ^{1Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →}
Antioxidant / radical scavenging (catechol groups)	antioxidant	general	in vitro
GABA-transaminase inhibition (lemon balm)	anxiolytic	anxiety	in vitro ^{8Reference 8Ghazizadeh J et al. · 2021Meta-analysisThe effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials — a systematic review and meta-analysisView study →}
HSV attachment/penetration inhibition	antiviral	(herbal)	in vitro (Melissa) ^{16Reference 16Astani A et al. · 2014Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extractView study →}

Pharmacokinetics

Rosmarinic acid is poorly bioavailable, and what is absorbed is largely not rosmarinic acid by the time it circulates. The core human study — oral perilla-extract rosmarinic acid — showed that it is absorbed but excreted in urine mainly as metabolites and conjugates: methylated, sulfated and glucuronidated forms, plus the degradation products caffeic acid, ferulic acid and m-coumaric acid ^{11Reference 11Baba S et al. · 2005Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humansView study →}. As an ester of two catechol-bearing halves it is a natural substrate for both gut-wall/hepatic conjugation and gut-microbial cleavage, so the microbiome contributes substantially to its breakdown into smaller absorbable phenolics, with the expected person-to-person variation ^{14Reference 14Thumann TA et al. · 2019The role of gut microbiota for the activity of medicinal plants traditionally used in the European Union for gastrointestinal disordersView study →}. Reviews of hydroxycinnamic-acid pharmacokinetics place rosmarinic acid firmly in the low-oral-bioavailability, extensively-first-pass-metabolized category ^{12Reference 12Amoah SK et al. · 2016Rosmarinic acid — pharmaceutical and clinical aspectsView study →}. The practical consequence is the same one that recurs across the polyphenols: a good deal of rosmarinic acid’s activity in a person may actually be the activity of its metabolites (caffeic and ferulic acids among them), and intact-rosmarinic-acid tissue exposure from an oral dose is modest ^{11,12Reference 11Baba S et al. · 2005Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humansView study →Reference 12Amoah SK et al. · 2016Rosmarinic acid — pharmaceutical and clinical aspectsView study →}.

Clinical trials

Rosmarinic acid’s human record is real but entirely extract-based — and worth reading with the vehicle in mind:

Perilla	Spearmint	Lemon balm
Allergic rhinitis ^{1Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →}	Attention, working memory, OA ^{2,3,5Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →Reference 3Falcone PH et al. · 2019RCTThe attention-enhancing effects of spearmint extract supplementation in healthy men and women — a randomized, double-blind, placebo-controlled, parallel trialView study →Reference 5Connelly AE et al. · 2014High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptomsView study →}	Anxiety, mood, sleep, cognition ^{7,8,10Reference 7Bano A et al. · 2023The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleepView study →Reference 8Ghazizadeh J et al. · 2021Meta-analysisThe effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials — a systematic review and meta-analysisView study →Reference 10Noguchi-Shinohara M et al. · 2023RCTEffects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia — a randomized controlled trialView study →}

Last checked: July 2026.

Isolate vs. Plant Studies

Rosmarinic acid is the clearest case here of a molecule whose reputation is really its source herbs’ reputation. No verified human trial has tested purified rosmarinic acid — the allergy data are a perilla extract ^{1Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →}, the cognition data a spearmint extract standardized to RA ^{2Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →}, the anxiety data lemon balm extracts ^{8Reference 8Ghazizadeh J et al. · 2021Meta-analysisThe effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials — a systematic review and meta-analysisView study →}, and the osteoarthritis data a spearmint tea ^{5Reference 5Connelly AE et al. · 2014High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptomsView study →}. In each, rosmarinic acid is the standardization marker and a plausible active, but it travels with caffeic-acid derivatives, flavonoids, volatile terpenes (in the mints) and, in rosemary and sage, the diterpenes carnosic acid and carnosol — so attributing the whole effect to “rosmarinic acid” overstates what is known. Its poor bioavailability compounds the point: much of the in-body activity may belong to its metabolites ^{11Reference 11Baba S et al. · 2005Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humansView study →}. Within this database rosmarinic acid is a genuine, often dominant, constituent of many Lamiaceae — the antioxidant backbone of rosemary and sage, the principal marker of lemon balm (where it also underlies the herb’s antiherpetic activity in vitro ^{16Reference 16Astani A et al. · 2014Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extractView study →}), the dominant phenolic of yerba santa, and the biosynthetic precursor of the salvianolic acids in dan shen — all legitimate occurrence-level facts rather than endorsements of isolated-RA supplements.

Prevalence in Nature

Rosmarinic acid is a chemotaxonomic marker: it is the family signature of the Lamiaceae (mint family) and Boraginaceae, and is essentially absent from non-mint-family foods — you will not find meaningful rosmarinic acid in cereals, most fruit and vegetables, alliums or legumes. Within the mint family it is often the single most abundant phenolic. On a dry-weight basis the richest sources are lemon balm (commercial lots ranging widely, ~0.16 up to ~49 mg/g, good material ~20–40) and yerba santa (~22–53 mg/g), followed by peppermint (up to ~17 mg/g), sage (~3–21, mean ~15), spearmint (~6–14), rosemary (~9–11), oregano (~6), perilla (~0.8–15, mean ~6) and sweet basil (~3 mg/g) ^{21,22,23,24,25Reference 21Arceusz A · 2013Quality consistency evaluation of Melissa officinalis L. commercial herbs by HPLC fingerprint and quantitation of selected phenolic acidsView study →Reference 22Hrebień-Filisińska AM et al. · 2025Rosmarinic acid and phenolic content of dried sage (Salvia officinalis)View study →Reference 23Liu J et al. · 2013Contents of rosmarinic acid in Perilla frutescens by plant part determined by HPLCView study →Reference 24Satyal P et al. · 2026Chemical composition of Eriodictyon californicum (California yerba santa) cultivated in Ontario, Oregon, USAView study →Reference 25Neveu V et al. · 2010Phenol-Explorer — an online comprehensive database on polyphenol contents in foods (rosmarinic acid, Lamiaceae seasonings report)View study →}. The single most important caveat for reading these numbers is basis: fresh culinary herbs are 80–90% water, so on a per-gram basis a fresh herb reads roughly 8–10× lower than the same herb dried — always state whether a figure is fresh or dry. Standardized extracts (a lemon-balm “5% RA” extract, a spearmint extract at ~23% RA) are a third, non-comparable basis and shouldn’t be mixed with whole-herb figures. Beyond the Lamiaceae, Boraginaceae such as comfrey and borage carry rosmarinic acid too, generally at lower and more variable levels. There are no non-plant sources.

Biosynthetically rosmarinic acid is unusual and elegant: it is an ester built from two amino-acid-derived halves — the caffeic-acid portion from phenylalanine (via the phenylpropanoid pathway) and the 3,4-dihydroxyphenyllactic acid portion from tyrosine — joined and then hydroxylated to the final catechol-rich diester ^{19,20Reference 19Petersen M · 2003Rosmarinic acidView study →Reference 20Petersen M et al. · 2009Evolution of rosmarinic acid biosynthesisView study →}. That two-amino-acid origin distinguishes it from most simple phenolic acids and is conserved across the Lamiaceae. In dan shen (Salvia miltiorrhiza) rosmarinic acid is further elaborated into the salvianolic acids, the water-soluble actives of that herb.

Discovery & Synthesis

Rosmarinic acid was first isolated from rosemary (Rosmarinus officinalis, now Salvia rosmarinus) and is named for it; the isolation is attributed to the Italian chemists Scarpati and Oriente in 1958, a report that predates PubMed indexing and so is treated here as reported rather than primary-sourced ^{19Reference 19Petersen M · 2003Rosmarinic acidView study →}. Chemically it is a caffeic-acid ester — more precisely the ester of caffeic acid and 3-(3,4-dihydroxyphenyl)lactic acid — a depside carrying two catechol groups, which is the structural basis for its strong antioxidant and metal-chelating behavior. It occurs predominantly as the (R) enantiomer. Its close biosynthetic relatives, the salvianolic acids of dan shen, are effectively rosmarinic-acid oligomers.

Commercial rosmarinic acid is obtained almost entirely by extraction from Lamiaceae biomass — lemon balm, rosemary, sage, perilla and spearmint are the usual feedstocks — and by purification from the same rosemary/sage extracts that supply the food industry’s antioxidant preparations. Plant cell-culture and hairy-root systems (which can accumulate rosmarinic acid to high levels) are an established alternative production route, and enzymatic/biotechnological syntheses exist, but agricultural extraction dominates supply.

Patents: not yet researched (future patent-loop pass).

Toxicity & Safety

As a constituent of everyday culinary herbs — rosemary, sage, basil, oregano, mint, lemon balm — rosmarinic acid has a long history of safe dietary exposure and a low-toxicity profile, and the standardized-extract trials above reported good tolerability at their studied doses ^{12,13Reference 12Amoah SK et al. · 2016Rosmarinic acid — pharmaceutical and clinical aspectsView study →Reference 13Noguchi-Shinohara M et al. · 2015RCTPharmacokinetics, safety and tolerability of Melissa officinalis extract which contained rosmarinic acid in healthy individuals — a randomized controlled trialView study →}. Rosemary extract standardized to rosmarinic/carnosic acids is even an established food antioxidant (E392 in the EU) ^{18Reference 18Wong YT et al. · 2025Development of a modified QuEChERS extraction for the detection of rosemary extracts (E392) in food by LC-MS/MSView study →}.

The practical cautions are modest and mostly herb-level. Allergic contact dermatitis to rosemary and other Lamiaceae is documented, with cross-reactivity across the family — relevant for topical exposure in sensitized individuals ^{17Reference 17González-Mahave I et al. · 2006Rosemary contact dermatitis and cross-reactivity with other Labiate plantsView study →}. As a polyphenol with antioxidant/mild antiplatelet character, a theoretical additive effect with antiplatelet or anticoagulant drugs is reasonable to note though not clinically established. Concentrated high-dose isolated-rosmarinic-acid supplementation is simply not well characterized in humans, since the trials used extracts.

Dosage

There is no established dose of isolated rosmarinic acid, because no human trial has tested the pure compound. The extract trials deliver, in rosmarinic-acid terms, roughly: perilla ~50–200 mg/day (allergy) ^{1Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →}; spearmint (Neumentix) ~130 mg/day (cognition) ^{2Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →}; lemon balm dosed to ~500 mg/day (cognition/anxiety) ^{10Reference 10Noguchi-Shinohara M et al. · 2023RCTEffects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia — a randomized controlled trialView study →}. Because rosmarinic acid is poorly absorbed and largely metabolized to caffeic/ferulic acids, extract intake and any “pure rosmarinic acid” figure are not interchangeable.

Context	Vehicle	Rosmarinic acid	Source
Allergic rhinitis	Perilla extract	~50–200 mg/day	^{1Reference 1Takano H et al. · 2004Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humansView study →}
Attention / memory	Spearmint extract (Neumentix)	~130 mg/day	^{2Reference 2Herrlinger KA et al. · 2018Spearmint extract improves working memory in men and women with age-associated memory impairmentView study →}
Anxiety / cognition	Lemon balm extract	dosed to ~500 mg/day	^{10Reference 10Noguchi-Shinohara M et al. · 2023RCTEffects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia — a randomized controlled trialView study →}

These are research figures from extract trials, not a recommendation — the honest position is that isolated-rosmarinic-acid dosing in humans is unstudied.

References

Takano H, Osakabe N, Sanbongi C, et al. (2004). Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenol, inhibits seasonal allergic rhinoconjunctivitis in humans. Experimental Biology and Medicine, 229(3), 247–254. https://pubmed.ncbi.nlm.nih.gov/14988517/
Herrlinger KA, Nieman KM, Sanoshy KD, et al. (2018). Spearmint extract improves working memory in men and women with age-associated memory impairment. Journal of Alternative and Complementary Medicine, 24(1), 37–47. https://pubmed.ncbi.nlm.nih.gov/29314866/
Falcone PH, Nieman KM, Tribby AC, et al. (2019). The attention-enhancing effects of spearmint extract supplementation in healthy men and women — a randomized, double-blind, placebo-controlled, parallel trial. Nutrition Research, 64, 24–38. https://pubmed.ncbi.nlm.nih.gov/30802720/
Falcone PH, Tribby AC, Vogel RM, et al. (2018). Efficacy of a nootropic spearmint extract on reactive agility — a randomized, double-blind, placebo-controlled, parallel trial. Journal of the International Society of Sports Nutrition, 15, 58. https://pubmed.ncbi.nlm.nih.gov/30541572/
Connelly AE, Tucker AJ, Tulk H, et al. (2014). High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. Journal of Medicinal Food, 17(12), 1361–1367. https://pubmed.ncbi.nlm.nih.gov/25058311/
Cases J, Ibarra A, Feuillère N, et al. (2011). Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterranean Journal of Nutrition and Metabolism, 4(3), 211–218. https://pubmed.ncbi.nlm.nih.gov/22207903/
Bano A, Hepsomali P, Rabbani F, et al. (2023). The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep. Frontiers in Pharmacology, 14, 1250560. https://pubmed.ncbi.nlm.nih.gov/37927585/
Ghazizadeh J, Sadigh-Eteghad S, Marx W, et al. (2021). The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials — a systematic review and meta-analysis. Phytotherapy Research, 35(12), 6690–6705. https://pubmed.ncbi.nlm.nih.gov/34449930/
Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. (2020). Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression. Scientific Reports, 10, 18627. https://pubmed.ncbi.nlm.nih.gov/33122694/
Noguchi-Shinohara M, Hamaguchi T, Sakai K, et al. (2023). Effects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia — a randomized controlled trial. Journal of Alzheimer’s Disease, 91(2), 805–814. https://pubmed.ncbi.nlm.nih.gov/36502333/
Baba S, Osakabe N, Natsume M, Terao J. (2005). Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. European Journal of Nutrition, 44(1), 1–9. https://pubmed.ncbi.nlm.nih.gov/15309457/
Amoah SK, Sandjo LP, Kratz JM, Biavatti MW. (2016). Rosmarinic acid — pharmaceutical and clinical aspects. Planta Medica, 82(5), 388–406. https://pubmed.ncbi.nlm.nih.gov/26845712/
Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. (2015). Pharmacokinetics, safety and tolerability of Melissa officinalis extract which contained rosmarinic acid in healthy individuals — a randomized controlled trial. PLoS One, 10(5), e0126422. https://pubmed.ncbi.nlm.nih.gov/25978046/
Thumann TA, Pferschy-Wenzig EM, Moissl-Eichinger C, Bauer R. (2019). The role of gut microbiota for the activity of medicinal plants traditionally used in the European Union for gastrointestinal disorders. Journal of Ethnopharmacology, 245, 112153. https://pubmed.ncbi.nlm.nih.gov/31408679/
Luo C, Zou L, Sun H, et al. (2020). A review of the anti-inflammatory effects of rosmarinic acid on inflammatory diseases. Frontiers in Pharmacology, 11, 153. https://pubmed.ncbi.nlm.nih.gov/32184728/
Astani A, Navid MH, Schnitzler P (2014). Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract. Phytotherapy Research, 28(10), 1547–1552. https://pubmed.ncbi.nlm.nih.gov/24817544/
González-Mahave I, Lobesa T, Del Pozo MD, et al. (2006). Rosemary contact dermatitis and cross-reactivity with other Labiate plants. Contact Dermatitis, 54(4), 210–212. https://pubmed.ncbi.nlm.nih.gov/16650096/
Wong YT, Leung TS, Fung WH, et al. (2025). Development of a modified QuEChERS extraction for the detection of rosemary extracts (E392) in food by LC-MS/MS. Journal of AOAC International, 108(2). https://pubmed.ncbi.nlm.nih.gov/39657255/
Petersen M, Simmonds MSJ. (2003). Rosmarinic acid. Phytochemistry, 62(2), 121–125. https://pubmed.ncbi.nlm.nih.gov/12482446/
Petersen M, Abdullah Y, Benner J, et al. (2009). Evolution of rosmarinic acid biosynthesis. Phytochemistry, 70(15–16), 1663–1679. https://pubmed.ncbi.nlm.nih.gov/19560175/
Arceusz A, Wesolowski M. (2013). Quality consistency evaluation of Melissa officinalis L. commercial herbs by HPLC fingerprint and quantitation of selected phenolic acids. Journal of Pharmaceutical and Biomedical Analysis, 83, 215–220. https://pubmed.ncbi.nlm.nih.gov/23770780/
Hrebień-Filisińska AM, Felisiak K, Tokarczyk G, et al. (2025). Rosmarinic acid and phenolic content of dried sage (Salvia officinalis). Molecules, 30. https://pubmed.ncbi.nlm.nih.gov/41375164/
Liu J, Wan Y, Zhao Z, et al. (2013). Contents of rosmarinic acid in Perilla frutescens by plant part determined by HPLC. Chemistry Central Journal, 7, 68. https://pubmed.ncbi.nlm.nih.gov/23548079/
Satyal P, et al. (2026). Chemical composition of Eriodictyon californicum (California yerba santa) cultivated in Ontario, Oregon, USA. Molecules, 31(8), 1834. https://pubmed.ncbi.nlm.nih.gov/42076034/
Neveu V, Perez-Jiménez J, Vos F, et al. (2010). Phenol-Explorer — an online comprehensive database on polyphenol contents in foods (rosmarinic acid, Lamiaceae seasonings report). Database (Oxford). [Database — no per-value PMID.] http://phenol-explorer.eu